Inactivation of penicillins and cephalosporins by enzymes.
نویسندگان
چکیده
منابع مشابه
Penicillins and cephalosporins.
Resemblances and differences between the penicillins (I) and cephalosporins (II) are considered from a chemical and biochemical point of view.
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The D-alanine carboxypeptidase of Bacillus subtilis is a particulate enzyme that is irreversibly inactivated by penicillins and cephalosporins. However, the lethal concentrations of these antibiotics are not the same as those that inhibit enzymatic activity in vitro. 6-Aminopenicillanic acid inactivates at least 95% of the enzyme at nonlethal concentrations. Conversely, cephalothin is lethal at...
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ژورنال
عنوان ژورنال: BMJ
سال: 1977
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.1.6071.1285-a